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Uncovering antidepressant effects of terpineol, an activator of cannabinoid receptors naturally present in the plant cannabis

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Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor

In Summary 
Terpineol is a compound naturally present in the essential oils of several plants, such as eucalyptus, mugwort, and cannabis and is also synthesized and added to food as a flavoring substance. It is mainly known for anti-inflammatory and antifungal properties.
Researchers hypothesized that terpineol may have antidepressant effects because of the “neuroinflammation” hypothesis of depression. A growing body of research has demonstrated that the activation of immune cells in blood and the inflammation of brain cells likely contribute to the development of the major depressive disorder - the most severe form of depression. One example is that in animal studies, depressive-like behavior is observed after administration of proinflammatory substances.
To test this possibility, scientists at the Federal University of Santa Catarina, Brazil, studied both the curative and preventive effects of terpineol in a mice model exhibiting depressive-like symptoms following administration of proinflammatory chemicals. They observed antidepressant effects when mice were treated with terpineol both before and after depression-inducing proinflammatory substances. More importantly, when the cannabinoid receptors CB1 and CB2 were blocked, such effects were lost.
The scientists concluded that terpineol induces anti-inflammatory effects through activation of cannabinoid receptors in the body. These findings highlighted the unexpected power and promising applications in depression therapy of terpineol - a natural constituent of several plants including cannabis.
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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Review Us!
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • Patient Stories
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog
  • Blog
  • Socials
  • CED Clinic Services