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A lesser known cannabinoid receptor, GPR55, as a promising drug target for the treatment of overactive bladder

Picture

Stimulation of atypical cannabinoid receptor GPR55 abolishes the symptoms of detrusor overactivity in spontaneously hypertensive rats

In Summary 
Overactive bladder is a troublesome disease affecting up to 15% of the population in many European countries, with females being more likely affected than males. Medications currently available in the clinics to manage this condition are associated with significant side effects, leading to low patients’ adherence to prescriptions. For this reason, the need for better tolerated drugs is urgent.
Through a novel study, an atypical, lesser known cannabinoid receptor, GPR55, has emerged as a potential target for such drugs. In this study, scientists injected female mice exhibiting abnormal bladder functions with a cannabinoid that specifically and efficiently activates GPR55 receptor. They found that these mice subsequently showed less inflammation in the urinary bladder, normalization of activities of detrusor - the muscle regulating the relaxation and contraction of the bladder and hence, normalization of bladder functions.
This study has uncovered the unexpected but important role of a lesser known cannabinoid receptor as a potential drug target for overactive bladder therapy especially in females. Nonetheless, the translation from animal studies into medications used in the clinics surely requires additional research.
 

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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Review Us!
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • Patient Stories
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog
  • Blog
  • Socials
  • CED Clinic Services