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Cannabis Sativa Revisited

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Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis

In Summary 
The cannabinoid receptors type 1 (CB1) and type 2 (CB2) can be activated by phytocannabinoids such as delta-9-tetrahydrocannabinol (D9-THC) and cannabidiol (CBD) in the plant cannabis, endocannabinoids such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG) produced by our bodies, as well as synthetic cannabinoids. Different lines of research have documented the effects of activations of these receptors on immune responses, inflammatory responses, and redox activities. Sepsis, the body’s extreme responses to infection by virus, bacteria, fungus or parasite that can ultimately lead to multisystem failure, initially involves simultaneous immune responses, inflammatory responses, and redox activities in multiple organ systems. Therefore, it is not surprising that the endocannabinoid signaling system has an intricate link to the body’s molecular and cellular reactions during sepsis. 
First, activation of CB1 and CB2 can reduce production of immunomodulating agents called cytokines by immune cells in many organs, but especially the microglial cells responsible for immune responses in the brain. Second, activation of these receptors can decrease reactive oxygen species and nitric oxide synthase, key signaling molecules in redox activity and oxidative stress. Altogether, the cannabinoid signaling system helps alleviate inflammatory responses in multiple organs, for example, in the brain, as well as the endothelium - the layer of cells that line blood vessels. 
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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Review Us!
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • Patient Stories
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog
  • Blog
  • Socials
  • CED Clinic Services