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Benefits of cannabidiol on skin cells are compromised in psoriasis patients receiving UV irradiation treatment.

Picture

Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris

In Summary 
Endocannabinoid is a group of lipids naturally produced by the body. The endocannabinoid system, which includes mainly endocannabinoids and receptors on the cell surface that they bind to, is widely expressed in skin cells. This system is known to play a vital role in immune responses and also regulate oxidative balance.
Cannabidiol (CBD) is a phytocannabinoid in the plant cannabis which shares structural and functional features with endocannabinoids. Furthermore, unlike other constituents, it does not affect psychological states. Therefore, CBD has recently received great attention as a potential therapy for many diseases caused by impaired immunity and oxidative stress.
One of such diseases is psoriasis, a chronic inflammatory skin disorder, in which skin cells multiply faster than normal and therefore build up into bumpy red patches covered with white scales. UV therapy is a common procedure used to treat this disease. For this reason, before CBD can be integrated into psoriasis treatment regimen, it is clinically important to understand the response of skin cells to CBD in combination with UV irradiation.
In a recent study, scientists found that CBD indeed reduces oxidative stress and inflammation in the skin cells of both healthy individuals and psoriasis patients. Interestingly, however, following UV irradiation, the protective effects of CBD on skin cells become less effective.

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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog