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Pharmaceutical activators of the cannabinoid receptor type 2 as potential therapy for neonatal hypoxic ischemic encephalopathy

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Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy

In Summary 
Hypoxic ischemic encephalopathy (HIE) is the brain damage caused by lack of blood flow, which delivers oxygen to the brain for an extended period of time. Neonatal HIE is associated with high risks of permanent disability or even death in infants. Therapeutic hypothermia is the current standard-of-care for newborns who have experienced oxygen deprivation leading to HIE. Unfortunately, not all Neonatal Intensive Care Units (NICUs) are equipped to provide therapeutic hypothermia and furthermore, over 40% of newborns receiving hypothermia still develop adverse neurological conditions. Therefore, current research is focused on developing alternative or adjuvant treatments to hypothermia for HIE.
One of the key cellular pathways leading to neuronal injuries in HIE is inflammation. The endocannabinoid system is a signalling pathway in the human body that has been shown to reduce inflammation-activating agents and decrease cellular responses to inflammation in adult mice with obstructed blood flow to the brain. More particularly, the cannabinoid receptor type 2 (CB2) is known to be highly expressed in immune cells in the central nervous system. 
Most recently, scientists found evidence that in mice with brain oxygen deprivation, the expression of CB2 in neurons increases drastically - 2 fold after 8 hours and 5 fold after injury. Furthermore, activation of CB2, either alone or in combination with hyperthermia treatment, reduces inflammatory agents and therefore protects neurons against HIE-related damages. These findings suggested that pharmaceutical compounds that activate CB2 serve as potential alternative or adjuvant therapy to hypothermia in treatment of neonatal HIE.
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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Review Us!
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • Patient Stories
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog
  • Blog
  • Socials
  • CED Clinic Services