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Mediation of the cannabinoid receptor type 1 can enhance the antidepressant powers of conventional therapy.

Picture

Influence of the endocannabinoid system on the antidepressant activity of Bupropion and Moclobemide in the behavioral tests in mice

In Summary 
Depression is one of the most common mood disorders, affecting over 320 million people worldwide; however, an effective medication for this condition is still elusive. Because the pathogenesis of depression involves multiple pathways of the nervous system, recent attempts to develop therapeutic strategies with high effectiveness and minimal side effects focus on the combined administration of drugs that mediate diverse neurotransmissions. In particular, scientists have reported that therapeutic compounds acting on the cannabinoid receptors, CB1 and CB2, are promising enhancers of conventional antidepressant drugs.
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Two conventional antidepressant medications tested were Bupropion and Moclobemide. Surprisingly, both the pharmaceutical activator and inhibitor of the CB1 receptor could improve Bupropion potency. Meanwhile, only the pharmaceutical inhibitor of the CB1 receptor could potentiate Moclobemid. The mechanisms underlying these complicated, seemingly paradoxical effects remain to be explored. Drugs that activate or inhibit the CB2 receptor appeared to have no significant antidepressant-enhancing impacts, possibly because this  receptor is far less abundant in the brain. Nonetheless, that regulations of CB1 receptor function influenced the activities of antidepressant drugs confirmed the  major roles of the endocannabinoid system in depression pathogenesis.
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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog