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The wide distribution of cannabinoid receptors in the gastrointestinal tract suggests cannabinoids like CBD can relieve GI pain

Picture

Localization of cannabinoid and cannabinoid related receptors in the cat gastrointestinal tract

In Summary 
Cannabidiol (CBD) is a component of the plant cannabis with great potential for medical applications because of its proven anti-inflammatory, anti-tumoral, analgesic (pain-relieving), and anxiolytic (anxiety-relieving) properties and its lack of psychological side effects. Although it is the most well-known, there are other plant-derived or synthetic cannabinoids with similar therapeutic properties as CBD. These compounds exert their beneficial effects by binding to and activating cannabinoid and cannabinoid-like receptors located on specific types of cells inside the body of not only humans, but also animals including cats.
In a recent study, scientists employed immunohistochemistry, a staining technique, to detect the presence of these receptors in feline gastrointestinal tract (GI) tissues. They found that  canonical cannabinoid receptors - namely CB1R, CB2R - and cannabinoid-like receptors - such as GPR55, PPARalpha, TRPA1, and 5-HT1aR - are widely distributed in many cells of the cat GI tract, which suggests that they are likely abundant in the human GI tract as well. When cannabinoids like CBD interact with these receptors, they presumably can reduce pain and inflammation. Although more research is underway to confirm such a conclusion, the novel finding of this study already strongly supports the use of cannabis to treat gut pain and discomfort.
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  • What to Expect
    • Your First Visit
    • Patient Intake Form
  • Services Offered
    • Telemedicine
    • Pediatric Patients
    • Additional Services
  • Registration Resources
    • Registration Help
    • Next Steps
    • Caregiver Information
    • Cannabis Control Commission
  • Contact
    • Contact the Clinic
    • Social Media Links
    • Meet The Team >
      • Meet Dr. Caplan
      • Meet Dr. Exelbert
  • CED Clinic Events
    • Upcoming Events
    • Fireside Chats
    • Dispensary Highlights
    • Past Events
  • Information and FAQ
    • CED Clinic Cannabis Care
    • Cannabis FAQ
    • Recommended Online Resources
    • CED Library
    • Printable Handouts >
      • Cannabis Journal
      • General Cannabis Info
      • Handouts for Illnesses >
        • Infectious Diseases
        • Mental Health
        • Skin Conditions
        • Neurological Disorders
        • Muscular and Skeletal Pain
        • Illnesses of Aging
        • Reproductive Health
        • Gastrointestinal Health
    • Awesome Extras! >
      • Vaporizing Overview
      • Unique Cannabinoids
      • MA Dispensary Map
      • Cannabis for Sleep
      • Topical Cannabis Products
      • Cooking with Cannabis
      • Cannabis Cookbook
  • Video Library
  • Massachusetts Dispensaries
  • Site Map
  • CED Blog