The influence of the fatty acid amide hydrolase 385C_A single nucleotide polymorphisms on obesity susceptibility
A recent study has revealed the positive correlation of fatty acid amine hydrolase (FAAH) polymorphisms with increased obesity rates in Iranian women. FAAH is a regulatory enzyme in the endocannabinoid system that is important for the inactivation of endogenous cannabinoids and has previously been associated with the obese phenotype. It was specifically found that two different genotypes of the 385 C/A polymorphism of FAAH increased the probability of obesity risk almost two times. Further research should focus on the possible screening of polymorphisms of the FAAH enzyme in order to advise those at an increased risk of developing obesity, and perhaps developing a weight management medication that targets FAAH and the endocannabinoid system.
The “munchies” is a well-known side effect of cannabis consumption popularized by derogatory or humorous characterizations of chronic cannabis users, such as stoner/surfer Jeff Spicoli in Fast Times at Ridgemont High. Cannabinoids and terpenes have been shown to have various effects on weight management and appetite stimulation, including appetite suppression. Cannabis-based medication to aid in the recovery of anorexia nervosa are currently being researched due to the anxiolytic effects and appetite stimulation, but some terpenes like humulene have recently been featured for their appetite suppressant capabilities. Further research should be conducted to fully develop the various weight management medications that cannabis has the ability to produce.
The study is available for review or download here:
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Biological underpinnings from psychosocial stress towards appetite and obesity during youth- research implications towards metagenomics, epigenomics and metabolomics
A recent study has revealed how saliva analysis demonstrates the relationship between diet, stress, and the endocannabinoid system. Stress can be measured by the concentration of cortisol in saliva; an increased concentration of cortisol has been positively correlated to increased activity of the endocannabinoid system which then leads to an increase in appetite. One suggested a mechanism for this occurrence is that the increase in cortisol modulates microbes that regulate endocannabinoids which eventually leads to uncontrolled eating habits. The dysregulation of the endocannabinoid system by stress has therefore been related to obesity and is a promising target for the treatment of obesity.
The authors mention utilizing saliva as a tool to discover the cause of patients obesity. By determining the cause in a timely fashion, physicians may be able to recommend more accurate treatment or diet plans to bring patients' weight back under control. Cannabinoids, in combination with stress-relieving techniques, may also provide an easier method for dropping weight than the more traditional diets that are often difficult to adhere to. Considering the obesity rates in America, especially among adolescents, looking into these alternative therapies for obesity is in the best interest of America’s national health.
This study is available for review and download in the CED Foundation Archive: http://bit.ly/drcaplan