CED Clinic: Personalized Cannabis Medicine

Clinicians should be aware of the complex relationship between cannabis use and alcohol consumption, as THC may have varying effects on alcohol craving and consumption.

Clinicians should be cautious when recommending low-dose CBD products, as the evidence for their effects is still inconclusive.

In this prospective, triple-blind, placebo-controlled trial, oral dronabinol (2.5 mg twice daily) failed to reduce opioid consumption or improve secondary pain and sleep outcomes following primary total knee arthroplasty.

A randomised trial in adults who were still being sick during chemotherapy despite already taking the standard anti-sickness medicines.

A crossover trial in which 22 people with severe Tourette syndrome took both an oral THC/CBD oil and a placebo, six weeks each, without knowing which was which.

A placebo-controlled trial asking whether a 1:1 THC:CBD oil eased the overall symptom burden of advanced cancer beyond what palliative care already provides.

A short randomised trial of a high-CBD, low-THC oral extract in 61 people with Parkinson's disease, a group who use cannabis often despite thin evidence.

A double-blind trial testing whether a CBD-rich extract taken before a root canal reduced anxiety during the procedure or pain afterwards.